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Case records of the Massachusetts General Hospital. Case 7-2007. A 59-year-old woman with diabetic renal disease and nonhealing skin ulcers.

Journal Article

False-positive tuberculin reactions due to non-tuberculous mycobacterial infections.

Journal Article

Thinking in three dimensions: a web-based algorithm to aid the interpretation of tuberculin skin test results.

Journal Article

BACKGROUND: The tuberculin skin test (TST) is the most widely used test for detecting tuberculosis (TB) infection. Accurate interpretation of TST requires consideration of three dimensions-the size of the skin reaction, the positive predictive value (PPV)...

Interpreting expression data with metabolic flux models: predicting Mycobacterium tuberculosis mycolic acid production.

Journal Article

Metabolism is central to cell physiology, and metabolic disturbances play a role in numerous disease states. Despite its importance, the ability to study metabolism at a global scale using genomic technologies is limited. In principle, complete genome...

A comparison of early versus late initiation of renal replacement therapy in critically ill patients with acute kidney injury: a systematic review and meta-analysis.

Journal Article

INTRODUCTION: Our aim was to investigate the impact of early versus late initiation of renal replacement therapy (RRT) on clinical outcomes in critically ill patients with acute kidney injury (AKI). METHODS: Systematic review and meta-analysis were used...

Disturbance of respiratory muscle control in a patient with early-stage multiple sclerosis.

Journal Article

Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis.

Journal Article

M. tuberculosis is evolving antibiotic resistance, threatening attempts at tuberculosis epidemic control. Mechanisms of resistance, including genetic changes favored by selection in resistant isolates, are incompletely understood. Using 116 newly...

A phylogeny-based sampling strategy and power calculator informs genome-wide associations study design for microbial pathogens.

Journal Article

Whole genome sequencing is increasingly used to study phenotypic variation among infectious pathogens and to evaluate their relative transmissibility, virulence, and immunogenicity. To date, relatively little has been published on how and how many...

Concordance of Mycobacterium tuberculosis fluoroquinolone resistance testing: implications for treatment.

Journal Article

Fluoroquinolone (FQ) drug susceptibility testing (DST) is an important step in the design of effective treatment regimens for multidrug-resistant tuberculosis. Here we compare ciprofloxacin, ofloxacin and moxifloxacin (MFX) resistance results from 226...

Gyrase Mutations Are Associated with Variable Levels of Fluoroquinolone Resistance in Mycobacterium tuberculosis.

Journal Article

Molecular diagnostics that rapidly and accurately predict resistance to fluoroquinolone drugs and especially later-generation agents promise to improve treatment outcomes for patients with multidrug-resistant tuberculosis and prevent the spread of disease...

The nature, patterns, clinical outcomes, and financial impact of intraoperative adverse events in emergency surgery.

Journal Article

BACKGROUND: Little is known about intraoperative adverse events (iAEs) in emergency surgery (ES). We sought to describe iAEs in ES and to investigate their clinical and financial impact. METHODS: The 2007 to 2012 administrative and American College of...

Connectivity of diagnostic technologies: improving surveillance and accelerating tuberculosis elimination.

Journal Article

In regard to tuberculosis (TB) and other major global epidemics, the use of new diagnostic tests is increasing dramatically, including in resource-limited countries. Although there has never been as much digital information generated, this data source has...